【摘 要】
：
Dicarabrols B and C (1 and 2),two new carabrane sesquiterpenoid dimers,along with one new carabrane sesquiterpen-oid (3) were isolated from the whole plant of Carpesium abrotanoides L.Their full structures were established by extensive analysis of HR-ESI-
【机 构】
：
Mathematical Engineering Academy of Chinese Medicine,Guangzhou University of Chinese Medicine,Guangz
论文部分内容阅读
Dicarabrols B and C (1 and 2),two new carabrane sesquiterpenoid dimers,along with one new carabrane sesquiterpen-oid (3) were isolated from the whole plant of Carpesium abrotanoides L.Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data,and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD)calculations.Dicarabrol B possesses a novel C30 skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties,while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule.Dicarabrol C exhibited potent inhibitory effects on HL-60 cells with an IC50 value of 3.7 μmol·L-1.
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