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二甲亚砜(DMSO)在体外能引起某些恶性细胞的分化,如病毒或化学致癌剂诱发的小鼠或大鼠红白血病细胞,在培养液内加入DMSO后,可分化为幼红细胞。地塞米松也有促进细胞分化的作用,将它加在小鼠粒细胞性白血病细胞培养内,能诱导瘤细胞向巨噬细胞和粒细胞分化。Okabe等在体外诱导分化的研究中注意到DMSO也能抑制小鼠白血病细胞的生长。Honma在同样试验中观察到地塞米松也有抑制瘤细胞生长的作用。细胞的生长和分化是互相联系的过程,正常细胞分化以后就不再分裂;恶性瘤细胞不断分裂增生,其分化程度亦低。二者的调节机制可能是紧密联系的。分化诱导剂—DMSO和地
Dimethyl sulfoxide (DMSO) can cause differentiation of certain malignant cells in vitro. For example, mouse or rat erythroleukemia cells induced by viruses or chemical carcinogens can be differentiated into young red blood cells after DMSO is added to the culture medium. Dexamethasone also promotes cell differentiation. Adding it to cultures of mouse granulocytic leukemia cells can induce differentiation of tumor cells into macrophages and granulocytes. Okabe et al. observed in vitro differentiation induction that DMSO can also inhibit the growth of mouse leukemia cells. Honma observed in the same experiment that dexamethasone also inhibited the growth of tumor cells. The growth and differentiation of cells are interconnected processes. Normal cells no longer divide after differentiation; malignant tumor cells continue to divide and proliferate, and their degree of differentiation is also low. The regulatory mechanism of the two may be closely linked. Differentiation Inducers - DMSO and Di