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[目的]探讨慢性萎缩性胃炎Hp阳性患者使用不同治疗方案的临床效果,为临床诊治提供参考。[方法]选取2011年5月~2014年5月48例慢性萎缩性胃炎Hp阳性感染患者,按数字表法随机抽取24例列为对照组,应用替普瑞酮联合三联疗法治疗,其余24例列为观察组,应用叶酸+替普瑞酮+三联疗法治疗,对比2组治疗效果。[结果]观察组治疗有效率91.67%,对照组治疗有效率79.17%,经过统计学处理,差异有统计学意义(P<0.05);观察组与对照组症状评分、活动性、炎性反应、肠上皮化生、萎缩、异型增生评分对比,经过统计学处理,差异有统计学意义(P<0.05);观察组治疗后胃泌素浓度为(1.22±0.21)nmol/L,与治疗前对比,经过统计学处理,差异有统计学意义(P<0.05),与对照组对比,经过统计学处理,差异有统计学意义(P<0.05)。[结论]以叶酸为主的治疗方案治疗Hp阳性慢性萎缩性胃炎患者效果好。
[Objective] To investigate the clinical effects of different treatment regimens in Hp positive patients with chronic atrophic gastritis and provide references for clinical diagnosis and treatment. [Method] Forty-eight patients with chronic atrophic gastritis positive for Hp infection were selected from May 2011 to May 2014. Twenty-four patients were randomly selected as the control group according to the digital table method and treated with teprenone combined with triple therapy. The remaining 24 patients As observation group, the application of folic acid + teprenone + triple therapy, compared two groups treatment effect. [Results] The effective rate of treatment in observation group was 91.67%, and that of control group was 79.17%. After statistical analysis, the difference was statistically significant (P <0.05); symptom score, activity, inflammatory response, Intestinal metaplasia, atrophy, dysplasia score comparison, after statistical analysis, the difference was statistically significant (P <0.05); the observation group after treatment gastrin concentration (1.22 ± 0.21) nmol / L, compared with before treatment After statistical treatment, the difference was statistically significant (P <0.05), compared with the control group, after statistical treatment, the difference was statistically significant (P <0.05). [Conclusion] Folic acid-based treatment of Hp-positive chronic atrophic gastritis patients with good results.