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目的探讨巨细胞病毒肝炎(CMV-IgM抗体阳性)患儿血清中白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平的变化以及在巨细胞病毒肝炎发病机制中的作用。方法应用ELISA法分别检测了69例巨细胞病毒肝炎患儿血清IL-6、IL-8水平,同时测定血清胆红素、谷丙转氨酶(ALT)水平,然后分析它们之间的关系,并与68例健康小儿比较。结果 69例巨细胞病毒肝炎组血清IL-6、IL-8水平明显高于正常对照组(P<0.01);其中31例重症患儿血清IL-6、IL-8水平明显高于38例轻症患儿(P<0.01)。结论巨细胞病毒肝炎患儿血清IL-6、IL-8水平较正常明显增高,并且与肝脏的损伤程度呈正相关。
Objective To investigate the changes of serum interleukin-6 (IL-6) and interleukin-8 (IL-8) levels in children with cytomegalovirus hepatitis (CMV-IgM antibody positive) and their significance in the pathogenesis of cytomegalovirus hepatitis Role. Methods Serum levels of IL-6 and IL-8 were measured in 69 children with cytomegalovirus by ELISA. The serum levels of bilirubin and alanine aminotransferase (ALT) were also measured. The relationships between them were also analyzed 68 healthy children comparison. Results The serum levels of IL-6 and IL-8 in 69 patients with cytomegalovirus were significantly higher than those in the normal control group (P <0.01). Serum levels of IL-6 and IL-8 in 31 severe cases were significantly higher than those in 38 cases Children with schizophrenia (P <0.01). Conclusion Serum levels of IL-6 and IL-8 in children with cytomegalovirus were significantly higher than those in normal controls and positively correlated with the degree of liver injury.