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髓系来源性抑制细胞(MDSCs)是来自髓系的具有异质性未分化成熟的细胞群,首次发现于肿瘤患者外周血循环中。目前,MDSCs在各种严重人类疾病中得到发现和研究,例如肿瘤、自身免疫性疾病、支气管哮喘以及严重感染等疾病。MDSCs可通过不同途径对机体的固有免疫和适应性免疫应答产生抑制作用,对肿瘤以及感染性、自身免疫性疾病等疾病的发生发展以及预后产生影响。乙型肝炎病毒(HBV)感染疾病的发展取决于病毒复制和宿主免疫的相互作用,机体适应性免疫系统在控制乙型肝炎病毒感染具有重要作用,过度活化的免疫抑制细胞可导致机体不能产生有效的免疫反应清除病毒导致HBV感染慢性化。本文就MDSCs在慢性HBV感染中的作用及其作为潜在的免疫治疗目标进行综述。
Myeloid-derived suppressor cells (MDSCs) are heterogeneous, undifferentiated, mature cell populations from the myeloid lineage that were first found in the peripheral blood circulation of tumor patients. At present, MDSCs are found and studied in various serious human diseases such as cancer, autoimmune diseases, bronchial asthma and severe infections. MDSCs can inhibit the innate and adaptive immune responses of the organism in different ways, and have an impact on the development and prognosis of tumors, infectious diseases and autoimmune diseases. The development of hepatitis B virus (HBV) -based diseases depends on the interaction between viral replication and host immunity. The adaptive immune system plays an important role in controlling hepatitis B virus infection. Over-activated immunosuppressive cells can cause the body to fail to produce effective The immune response removes the virus leading to chronic HBV infection. This article reviews the role of MDSCs in chronic HBV infection and its potential as a target for immunotherapy.