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目的:探索培哚普利对原发性高血压(EH)合并外周动脉病变(PAD)的影响。方法:将43例II期EH合并Pan的男性病人随机分为2组。治疗组22例(年龄54±s9a)采用培哚普利4~8mg,po,qd,共4wk。对照组21例(年龄54±10a)其中14例采用卡托普利25mg,po,bid或tid治疗,7例采用硝苯地平10mg,po,tid或qid治疗,共4wk。结果:2组均有显著的降压疗效,P值均<0.01;培哚普利对24h动态血压趋于正常者治疗后降压疗效不明显(P>0.05),而对符合动态EH诊断标准者,降压疗效显著(P<0.05或0.01);治疗组经培哚普利治疗4wk后,16例(73%)恢复正常;培哚普利不良反应轻微。结论:培哚普利治疗EH男性病人是安全、可靠的药物,对PAD也有较高的疗效。
Objective: To explore the effect of perindopril on essential hypertension (EH) with peripheral arterial lesions (PAD). Methods: Forty-three male patients with phase II EH and Pan were randomly divided into two groups. Treatment group, 22 patients (age 54 ± s9a) with perindopril 4 ~ 8mg, po, qd, a total of 4wk. Control group of 21 patients (age 54 ± 10a) of which 14 patients were treated with captopril 25mg, po, bid or tid, 7 patients treated with nifedipine 10mg, po, tid or qid, a total of 4wk. Results: There was significant antihypertensive efficacy in both groups, P <0.01; Perindopril had no obvious antihypertensive efficacy after 24 hours of ambulatory blood pressure (P> 0.05) The dynamic EH diagnostic criteria, antihypertensive effect was significant (P <0.05 or 0.01); treatment group after 4 weeks of perindopril treatment, 16 cases (73%) returned to normal; perindopril minor adverse reactions. CONCLUSION: Perindopril is a safe and reliable drug for the treatment of EH male patients and has a high therapeutic effect on PAD.