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目的 研究生脉注射液对窒息后脑损伤的保护作用.方法 采用自制的窒息模型,将实验分为对照组、窒息组及生脉组.检测窒息后复氧24小时时,大脑皮层组织的过氧化脂质(LPO)含量、白细胞数及病变(变性或/和坏死)神经元数,并在光镜下对脑组织毛细血管充盈不良进行分级.结果 窒息组上述指标同对照组、生脉组相比明显增加或程度加重(P<0.05或0.01),LPO与白细胞数、病变神经元数之间以及白细胞与病变神经元之间呈正相关(P均<0.05).结论 生脉注射液通过抗氧自由基、降低白细胞数及改善脑微循环障碍等途径保护窒息后脑损伤.
Objective To protect the post-asphyxial brain injury by using graduated blood vessel injection. Methods The self-made asphyxia model was used to divide the experiment into control group, asphyxia group, and growth group. Peroxidation of cerebral cortex tissue after 24 hours of reoxygenation was detected. Quality (LPO) content, number of white blood cells, number of lesions (denatured or/and necrotic) neurons, and classification of poor capillary filling in the brain under light microscopy. Results The above indicators in the asphyxia group were compared with the control group and the Shengmai group. Significant increase or degree of aggravation (P<0.05 or 0.01), LPO and white blood cell count, the number of diseased neurons and white blood cells and diseased neurons were positively correlated (P<0.05). Conclusion Shengmai injection through antioxidant free Base, reduce the number of white blood cells and improve cerebral microcirculation obstacles and other ways to protect against asphyxia brain injury.