内皮素是近年发现的一种血管活性肽,具有强烈收缩血管及气道平滑肌作用,还有抑制心功能作用。缺氧及体内毒性代谢产物是刺激血管内ETmRNA表达和内皮素释放的重要因素。本研究证实毛细支气管炎重症病例血浆内皮素增高,并发心力衰竭时血浆内皮素显著增高。揭示内皮素参与了重症毛细支气管炎的发生发展。笔者认为内皮素的变化可用于指导临床判断病情严重程度,及早发现心力衰竭,及时指导治疗。在目前尚缺乏内皮素或内皮素受体有效、可靠的拮抗剂情况下,糖皮质激素是唯一可降低内皮素水平的药物。 Endothelin is a vasoactive peptide found in recent years, with a strong contraction of blood vessels and airway smooth muscle, as well as inhibition of cardiac function. Hypoxia and toxic metabolites in vivo are important factors that stimulate ETmRNA expression and endothelin release. This study confirmed that patients with capillary bronchitis increased plasma endothelin, concomitant heart failure plasma endothelin was significantly higher. Endothelin is involved in the occurrence and development of severe bronchiolitis. I believe that changes in endothelin can be used to guide the clinical judgment of the severity of the disease, early detection of heart failure, timely guidance and treatment. In the absence of an effective and reliable antagonist of endothelin or endothelin receptors, glucocorticoids are the only drugs that reduce endothelin levels.