目的 :探讨脑溢安颗粒 (简称脑溢安 )治疗脑出血的疗效机制。方法 :立体定位于苍白球内注射VⅡ型胶原酶诱导大鼠脑出血模型 ,采用免疫组织化学法检测模型组、脑溢安组与各对照组脑组织内bax蛋白表达。结果 :模型组脑组织内bax阳性细胞在 6h开始增加 ,1d达峰值 ,4d时明显减少。 1 2h ,1d ,2d ,4d ,7d脑溢安组其bax阳性细胞明显低于模型组。结论 :脑溢安可下调bax表达 Objective: To investigate the curative effect of Nao Yi An Granule (Nao Yi An) in the treatment of cerebral hemorrhage. Methods: The model of intracerebral hemorrhage was induced by injection of V Ⅱ collagenase in the globus pallidus. The expression of bax protein in brain tissue of model group, Naoyian group and each control group was detected by immunohistochemistry. Results: The bax positive cells in brain tissue of model group began to increase at 6h, peaked at 1d, and significantly decreased at 4d. 1 2h, 1d, 2d, 4d, 7d Erythromycin group bax-positive cells was significantly lower than the model group. Conclusion: Noctuixin can down-regulate the expression of bax