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目的：研究妊娠滋养细胞肿瘤（ＧＴＴ）中Ｐ糖蛋白（Ｐ－ＧＰ）和谷胱甘肽Ｓ转移酶（ＧＳＴ－π）的表达与化疗耐药性的关系。方法：应用免疫组化法检测Ｐ－ＧＰ和ＧＳＴ－π在ＧＴＴ中的表达。结果：正常早孕绒毛、完全性葡萄胎、侵蚀性葡萄胎及绒毛膜癌中的Ｐ－ＧＰ表达逐渐降低（Ｐ＜０．０５）。Ｐ－ＧＰ在病灶直径≥３ｃｍ和ＷＨＯ评分≥８分者的染色强度低于＜３ｃｍ及＜８分者。化疗耐药者Ｐ－ＧＰ表达与敏感者差异无显著性（Ｐ＞０．０５），耐药者ＧＳＴ－π表达明显高于敏感者（Ｐ＜０．０１）。结论：Ｐ－ＧＰ与ＧＴＴ分化程度及患者预后有关。ＧＳＴ－π为ＧＴＴ获得性耐药机制之一，对ＧＴＴ病例的耐药性评价有重要意义。
Objective: To study the relationship between the expression of P-GP and GST-π and the chemoresistance in gestational trophoblastic tumor (GTT). Methods: The expression of P-GP and GST-π in GTT was detected by immunohistochemistry. Results: The expression of P-GP in normal early pregnancy villus, complete hydatidiform mole, invasive hydatidiform mole and choriocarcinoma decreased gradually (P <0.05). P-GP in the lesion diameter ≥ 3cm and WHO score ≥ 8 points staining intensity less than <3cm and <8 points. The expression of P-GP in chemoresistant patients was not significantly different from that in susceptible patients (P> 0.05). The expression of GST-π in drug-resistant patients was significantly higher than that in susceptible patients (P <0.01). Conclusion: P-GP and GTT differentiation and prognosis of patients. GST-π is one of the mechanisms of acquired resistance to GTT, and is of great significance for the evaluation of drug resistance in GTT cases.