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目的:通过检测干细胞标记物ALDH1在口腔扁平苔藓(OLP)和白斑(LK)中的表达水平,评价其与癌变的关系。方法:采用免疫组织化学SP法检测ALDH1在10例正常口腔黏膜,30例OLP,60例LK,10例口腔鳞癌(OSCC)中表达水平;再检测ALDH1在30例癌变与30例未癌变LK中的表达差异。结果:ALDH1在正常口腔黏膜中不表达,在OLP、LK和OSCC中的表达率分别为26.7%,63.3%和90.0%(P<0.05);ALDH1在未癌变和癌变LK中的表达率分别是43.3%和83.3%(P<0.01)。结论:ALDH1与口腔黏膜恶性潜能程度相关,可能是预测癌变的分子标记物。
OBJECTIVE: To evaluate the relationship between ALDH1 expression in oral lichen planus (OLP) and leukoplakia (LK) by detecting the expression of stem cell marker ALDH1. Methods: Immunohistochemical SP method was used to detect the expression of ALDH1 in 10 normal oral mucosa, 30 OLP, 60 LK and 10 OSCC. The ALDH1 was detected in 30 cancerous and 30 non-cancerous LK In the expression differences. Results: The expressions of ALDH1 in OLK, LK and OSCC were 26.7%, 63.3% and 90.0%, respectively (P <0.05). The expression rates of ALDH1 in non-cancerous and cancerous LK were 43.3% and 83.3% (P <0.01). Conclusion: ALDH1 is associated with the malignant potential of oral mucosa and may be a molecular marker for predicting carcinogenesis.