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目的探讨甲氨蝶呤(MTX)联合米非司酮配伍中药保守治疗输卵管妊娠的疗效。方法将符合保守治疗条件的110例输卵管妊娠患者,随机分为观察组58例和对照组52例,分别采用MTX联合米非司酮配伍中药和MTX联合米非司酮治疗,观察对比2组的治疗效果。结果观察组与对照组治愈率分别为91.38%(53/58)、80.77%(42/52),观察组治愈率高于对照组,但差异无统计学意义(P>0.05);2组血β-HCG转阴时间比较,差异无统计学意义(P>0.05);2组治疗后3个月给予输卵管碘油造影,观察组输卵管复通率为62.07%(36/58),对照组输卵管复通率为38.46%(20/52),差异有统计学意义(P<0.05);2组附件包块消失天数比较,差异有统计学意义(P<0.01)。结论与MTX联合米非司酮治疗比较,MTX联合米非司酮配伍中药治疗输卵管妊娠,其包块吸收快、输卵管复通率高,较好地保留了患者的生育功能,且副反应小,价格低廉。
Objective To investigate the efficacy of methotrexate (MTX) in combination with mifepristone and traditional Chinese medicine in the treatment of tubal pregnancy. Methods 110 patients with tubal pregnancy who met the conservative treatment conditions were randomly divided into observation group of 58 cases and control group of 52 cases were treated with MTX combined with mifepristone and MTX combined with mifepristone treatment were observed in two groups compared treatment effect. Results The cure rates in observation group and control group were 91.38% (53/58) and 80.77% (42/52), respectively. The cure rate in observation group was higher than that in control group, but the difference was not statistically significant (P> 0.05) (P> 0.05). In the two groups, tubal lipiodol angiography was performed 3 months after the treatment, the rate of tubal recurrence in the observation group was 62.07% (36/58), while that in the control group was lower than that in the control group The pass rate was 38.46% (20/52), the difference was statistically significant (P <0.05). There was significant difference between the two groups in the days of appendix mass disappearance (P <0.01). Conclusion Compared with MTX and mifepristone treatment, MTX combined with mifepristone and traditional Chinese medicine in the treatment of tubal pregnancy, the rapid absorption of its mass, the tubal recanalization rate is high, better retained the patient’s reproductive function, and the side effects of small, Low price.