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用微量细胞病变抑制法检测88例自身免疫病患者血清干扰素。38名健康人血清干扰素滴度均<4u/ml。88例患者中血清干扰素滴度4～64u/ml者有35例,与健康人相比有显著差异(P<0.01)。用NDV对部份患者外周血白细胞体外诱导,观察干扰素的产生,20名自身免疫病患者白细胞产生干扰素的能力较健康人显著为低(P<0.05)。对3例SLE血清干扰素性质的研究指出,此3例血清干扰素皆为酸不稳定,且能被抗IFN-α抗体所中和。
Serum interferon in 88 patients with autoimmune diseases was detected by micro cytopathy inhibition. 38 healthy human serum interferon titers <4u / ml. There were 35 cases in 88 patients with titers of 4 ~ 64u / ml, which were significantly different from those in healthy people (P <0.01). Induction of peripheral blood leukocytes in some patients with NDV in vitro showed that interferon was produced by interferon in 20 patients with autoimmune diseases, which was significantly lower than that of healthy individuals (P <0.05). The study on the properties of 3 SLE serum interferons pointed out that all 3 serum IFNs were acid labile and could be neutralized by anti-IFN-α antibody.