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四环素与土霉素为临床常用的广谱抗菌素,我国口服四环素与土霉素系以其碱为原料制成片剂或胶市剂,四环素与土霉素的碱生产工艺简便、产量大、成本低、在防治感染性疾病上应用甚广。近年来医疗单位认为口服四环素与土霉素制剂的临床疗效并不满意。我组与上海制药三厂等单位协作,对四环素盐酸盐与碱、土霉素盐酸盐与碱的毒性,体外抗菌作用及正常人口服后生物有效性(血液浓度、尿排泄量)等进行考察,现
Tetracycline and oxytetracycline are broad-spectrum antibiotics commonly used in clinic. Oral tetracycline and oxytetracycline are made into tablets or gel-fillers using the alkali as raw materials. Tetracycline and oxytetracycline have the advantages of simple alkali production process, large output and high cost Low, in the prevention and treatment of infectious diseases is widely used. In recent years, medical units that oral tetracycline and oxytetracycline preparations clinical efficacy is not satisfied. I group and Shanghai Pharmaceutical Factory and other third-party collaboration on the tetracycline hydrochloride and alkali, oxytetracycline hydrochloride and alkali toxicity, antibacterial effect in vitro and normal after oral bioavailability (blood concentration, urinary excretion), etc. To investigate, now