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目的分析山东省2007/2008年度(2007年10月～2008年9月)流行性脑脊髓膜炎(流脑)疫情及健康人群带菌调查结果,了解脑膜炎奈瑟菌(Neisseria Meningitides,Nm)菌群分布、变异状况及耐药特征。方法用Nm双抗培养基,对采集的脑脊液及咽拭子标本进行分离培养、鉴定及药物敏感性试验。脑脊液及血清标本辅以实时荧光定量聚合酶链反应检测。结果2007/2008年度,从流脑病例及接触者分离到Nm7株,其中B群3株,C群4株。健康人群2323人中带菌者44人,带菌率1.89%;其中A群11株(占25.00%),B群16株(36.36%),C群4株(9.09%),其它血清群13株(29.55%)。以15～19岁带菌率最高,为5.74%;性别、地区间差异均无统计学意义。A、B、C群Nm表现不同耐药特征。结论目前流脑疫情以C、B群为主,健康人群带菌以B群为主,其次为A、C群。应在以预防接种为主的综合措施基础上,继续加强流脑病原学及耐药特征监测。
Objective To analyze the epidemic situation of epidemic cerebrospinal meningitis (MCI) in Shandong Province in 2007/2008 (from October 2007 to September 2008) and the survey results on the carriage of healthy people in Shandong Province, and to understand the effects of Neisseria Meningitides (Nm) Population distribution, variation and drug resistance characteristics. Methods Nm double-resistant medium was used to isolate, culture, identify and test the drug sensitivity of collected cerebrospinal fluid and throat swab specimens. CSF and serum samples supplemented with real-time fluorescence quantitative polymerase chain reaction. Results In 2007/2008, Nm7 strains were isolated from cases and contacts of meningitis, including 3 strains of B group and 4 strains of C group. Among 2323 healthy people, 44 carriers were carriers with a rate of 1.89%; among which, 11 strains (25.00%) of group A, 16 strains (36.36%) of group B, 4 strains (9.09%) of group C and 13 29.55%). The highest incidence of infection was 15 ~ 19 years old, which was 5.74%. There were no significant differences between sexes and regions. A, B, C group Nm showed different drug resistance characteristics. Conclusions The prevalence of meningococcal meningitis in Group C and Group B is predominant, with Group B predominant in healthy people, followed by Group A and Group C. Based on the comprehensive measures focusing on vaccination, we should continue to strengthen the monitoring of the etiology and drug resistance of meningitis.