目的观察2型糖尿病(DM)患者亚临床动脉粥样硬化(AS)与胰岛素抵抗(IR)的相关性。方法174例2型DM患者按有无颈动脉内膜-中膜(CA-IMT)增厚分为增厚组(92例),单纯DM组(82例),另设正常对照组(60例)。对3组均测空腹血糖(FBG)、空腹胰岛素(FIns),计算胰岛素抵抗指数(HOMA-IR)。结果增厚组HOMA-IR明显高于单纯DM组及正常对照组(均P<0.01),单纯DM组高于正常对照组(P<0.01)。结论2型DM伴亚临床AS与IR呈正相关,提示IR是2型DM及AS的危险因素。 Objective To investigate the relationship between subclinical atherosclerosis (AS) and insulin resistance (IR) in type 2 diabetes mellitus (DM). Methods One hundred and twenty-four patients with type 2 diabetes mellitus (DM) were divided into thickening group (n = 92), simple DM group (n = 82) and normal control group (n = 60) ). Fasting blood glucose (FBG), fasting insulin (FIns), and insulin resistance index (HOMA-IR) were measured in all three groups. Results HOMA-IR in thickened group was significantly higher than that in simple DM group and normal control group (all P <0.01), and that in simple DM group was higher than that in normal control group (P <0.01). Conclusions Type 2 DM with subclinical AS is positively correlated with IR, suggesting that IR is a risk factor for type 2 DM and AS.