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幽门螺旋杆菌(HP)在慢性胃炎、胃癌等发生学的地位日益受到重视,目前已被世界卫生组织列为第一类致癌因子,HP与胃癌等及其关系的研究引起世界与我国医学领域内多个学科的共同重视.HP是特异地定植于胃粘膜的主要致病菌,20世纪以来不断有报告在胃粘膜组织中检出弯曲杆菌,1983年澳大利亚学者marshall和warren在受检者中培养出同一种能产生大量尿素酶的细菌后被命名为幽门弯曲菌(Campylobacterpylori,CP).1985年我国学者对HP分离成功.1989年以后,一些学者深入研究了CP的生物学特性后指出,应将其归为一个新的细菌属即螺旋杆菌属(Helicobacter),因而将其更名为幽门螺旋杆菌(Helicobacter pylori,HP).近年来,随着对HP研究的逐步深入,热点之多,诸如HP与十二脂肠溃疡,慢性萎缩性胃炎,胃粘膜相关性淋巴瘤(MALT).炎症损害因子,内生突变源等,尤其是分子生物水平研究HP感染与癌基因型分析(Genotolpe),癌基因表达及细胞内DNA含量关系,HP引起癌基因突变……标志着病理学的认识领域进入了历史新阶段.HP可分为两种类型,I型HP能产生致空泡变性细胞
The role of Helicobacter pylori (HP) in the pathogenesis of chronic gastritis, gastric cancer, etc. has been receiving increasing attention. Currently, it has been listed by the World Health Organization as the first type of carcinogenic factor, and the relationship between HP and gastric cancer and their relationship has caused the world and the medical field in our country. The common emphasis of many disciplines is that HP is the main pathogen that is specifically colonized on the gastric mucosa. Since the 20th century, Campylobacter has been reported to be detected in gastric mucosa. In 1983 Australian scholars marshall and warren were cultured in subjects. The same type of bacteria that produced a large amount of urease was named Campylobacter pylori (CP). In 1985, Chinese scholars successfully separated HP. After 1989, some scholars studied the biological characteristics of CP and pointed out that It is classified as a new bacterial genus, Helicobacter, and is therefore renamed Helicobacter pylori (HP). In recent years, with the gradual deepening of HP research, there are many hot spots, such as HP. With twelve dyslipidemia, chronic atrophic gastritis, gastric mucosa-associated lymphoma (MALT). Inflammatory lesions, endogenous mutations, etc., especially at the molecular level to study HP infection and oncogenes. Genotolpe, the relationship between oncogene expression and intracellular DNA content, HP-induced oncogene mutations, and the recognition of pathology have entered a new historical stage. HP can be divided into two types, type I HP can produce Vacuolar degeneration