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本文报道了应用醋酸纤维薄膜电泳普查时,在河南省内黄县发现的一例快速异常血红蛋白。通过肽链柱层析分离、酶解、氨基酸组分及顺序分析,证实其β链 N 端第61位的赖氨酸为天冬酰胺替代,为 Hb Hikari(β61(E5)LyS→Asn。本例异常血红蛋白在中国属首例报告。
This article reports the use of acetate thin film electrophoresis census, a case of rapid abnormal hemoglobin found in Neixian County, Henan Province. By peptide column chromatography, enzymatic hydrolysis, amino acid composition and sequence analysis confirmed that the N-terminal 61 of the β-chain of lysine asparagine replacement for the Hb Hikari (β61 (E5) LyS → Asn. Cases of abnormal hemoglobin in China is the first case report.