对４５例经内镜诊断反流性食管炎（４１例）和伴食管溃疡（１３例），单纯食管溃疡（３例）及轻度凹陷性糜烂（１例）之患者做食管粘膜卢戈氏染色。染色后轻度凹陷性糜烂与食管炎中平坦状糜烂各１例分别诊断为浅凹陷型（Ｏ－Ⅱａ）与轻度隆起型（Ｏ－Ⅱａ）食管癌（ｍｍ癌与ｓｍ癌），与手术结果一致。９例染色前判定无明显异常区，染色后见１３处非染色区，１１处活检为糜烂性炎症。８例贲门口闭合不全中４例齿状线观察不清，染色后３例判定为裂孔疝。作者体会，卢戈氏染色有助于区别良恶性，尤其对早期食管癌的诊断具有重要价值。 45 cases of endoscopic diagnosis of reflux esophagitis (41 cases) and with esophageal ulcer (13 cases), simple esophageal ulcer (3 cases) and mild pitting erosion (1 case) of patients with esophageal mucosa Lug dyeing. One case with mild pitting erosion and flat erosion after esophagitis was diagnosed as O-IIa and O-IIa esophageal (MM and SM), respectively, and surgery The result is the same. There were no obvious abnormalities in 9 cases before staining, 13 non-staining areas after staining, and 11 cases of biopsy as erosive inflammation. 8 cases of cardiac insufficiency in 4 cases of dentate line obscure, stained 3 cases were judged as hiatal hernia. The author’s experience, Lugol’s stain helps distinguish benign from malignant, especially for the diagnosis of early esophageal cancer is of great value.