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目的观察柳氮磺吡啶结合灌肠治疗慢性溃疡性结肠炎的临床疗效。方法用随机数字表法随机(1∶1)分为两组各45例。对照组采用柳氮磺吡啶1g/次,4次/d;治疗组在对照组的基础上加用:生理盐水50ml+庆大霉素16万u+思密达2袋+地塞米松10 mg(逐渐减至5 g后停用),2次/d,保留30 min～1 h灌肠,药液温度控制在35～40℃,灌肠后平卧或臀部抬高休息。结果①两组疗效比较:对照组平均秩次为38.16,治疗组平均秩次为52.84。两组疗效有显著性差异。②总有效率治疗组为91.11%,对照组为71.11%,两组比较:χ2=5.874,ν=1,P=0.015,有显著性差异。结论柳氮磺吡啶结合灌肠治疗慢性溃疡性结肠炎有较好的临床疗效,且副作用小,依从性好,值得进一步研究。
Objective To observe the clinical efficacy of sulfasalazine combined with enema in the treatment of chronic ulcerative colitis. Methods Using random number table method randomly divided into two groups of 45 cases (1: 1). The control group with sulfasalazine 1g / times, 4 times / d; the treatment group in the control group based on the addition of: saline 50ml + gentamicin 160000 u + Smectite 2 bags + dexamethasone 10 mg Reduced to 5 g after the disabled), 2 times / d, retained 30 min ~ 1 h enema, liquid temperature control at 35 ~ 40 ℃, enema lying or hip lift rest. Results ① The two groups were compared: the average rank of the control group was 38.16, the average rank of the treatment group was 52.84. There was significant difference between the two groups. ② The total effective rate was 91.11% in the treatment group and 71.11% in the control group. There was significant difference between the two groups: χ2 = 5.874, ν = 1, P = 0.015. Conclusions Sulfasalazine combined with enema has better clinical curative effect in treating chronic ulcerative colitis with less side effects and good compliance, which deserves further study.