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目的评估并比较初治轻链型与非轻链型多发性骨髓瘤(MM)患者实验室检查各指标异常情况。方法比较本院自2011年1月-2016年1月共105例初治轻链型与非轻链型MM患者各实验室检查结果(轻链型31例,非轻链型74例)。结果轻链型患者中Cr水平及异常比例明显高于非轻链型,差异有统计学意义(P=0.03),而轻链型Cys-C水平与非轻链型差异无统计学意义(P=0.57)。轻链型患者原始和幼稚浆/总浆高于非轻链型,差异有统计学意义(P=0.02)。轻链型患者的LDH、β_2M和ALB水平明显高于非轻链型,差异有统计学意义(P<0.05),而ISS分期差异无统计学意义(P=0.38)。结论轻链型患者初诊时肿瘤负荷更大,疾病进展可能更快。
Objective To evaluate and compare the abnormalities of laboratory indexes in primary light and non-light chain multiple myeloma patients. Methods A total of 105 laboratory tests of light and non-light-chain MM patients in our hospital from January 2011 to January 2016 were compared (31 for light and 74 for non-light). Results The Cr level and abnormal proportion in patients with light chain were significantly higher than those in non-light-chain patients (P = 0.03), while there was no significant difference between light-chain Cys-C and non-light-chain = 0.57). Light chain patients with primary and immature plasma / total pulp higher than non-light chain, the difference was statistically significant (P = 0.02). The levels of LDH, β 2 M and ALB in patients with light chain were significantly higher than those in non-light-chain patients (P 0. 05), but there was no significant difference in ISS stage (P 0.38). Conclusions Patients with light-chain disease have a higher tumor load and a faster progression of the disease when they are newly diagnosed.