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用前瞻对照法对12例病人交叉静脉注射奥美拉唑和甲氰咪胍比较抑酸效果。结果：常规剂量奥美拉唑40mg与超大剂量甲氰咪胍1600mg，胃内抑酸平台期pH分别为5．8±1．3和5．4±1．6（P＞0．05），最高8小时胃内pH分别为6．4±1.2和6．0±2．0（P＞0．05），但起效时间前者0．6±0．6小时显著优于后者1．7±1．3小时（P＜0．05）。降低甲氰咪胍到1200mg和800mg，效力逐步减少，到胃内pH4．0和1．5，抑酸效力很弱。本研究显示，奥美拉唑常规剂量可达消化性溃疡出血治疗的抑酸要求，应作为首选抑酸药。
Using prospective comparison of 12 patients with intravenous injection of omeprazole and cimetidine acid suppression effect. Results: The normal dosage of omeprazole 40mg and large dose of cimetidine 1600mg, gastric acid suppression plateau phase pH 5.8 ± 1.3 and 5.4 ± 1.6 (P> 0.05), respectively, The maximum intragastric pH was 6.4 ± 1.2 and 6.0 ± 2.0 for 8 hours (P> 0.05), but the former was 0.6 ± 0.6 hours significantly better than the latter 1.7 ± 1.3 hours (P <0.05). Reduce cimetidine to 1200mg and 800mg, the effectiveness of gradually reduced to the stomach pH4.0 and 1.5, inhibitory effect is very weak. This study shows that omeprazole conventional doses up to the acid suppression of peptic ulcer bleeding treatment should be as the preferred acid suppression drug.