本实验观察了PGE_2对体外培养的新生大鼠心肌细胞的机能及超微结构的影响。发现4ng/ml PGE_2可以立即引起细胞搏动频率明显减慢,作用6分钟对心肌细胞及微丝的形态结构没有明显影响;作用6小时,其微丝排列规则而整齐,与正常比较未见异常,但心肌细胞膜出现皱折,微足突变粗短甚至消失,微泡也消失。表明PGE2对心肌细胞的作用具有时间依赖性。 This experiment observed the effect of PGE_2 on the function and ultrastructure of neonatal rat cardiomyocytes cultured in vitro. The results showed that 4ng / ml PGE_2 could cause the cell beating frequency to slow down immediately, and the effect of 6min on the morphology and structure of cardiomyocytes and microfilaments had no obvious effect. For 6 hours, the microfilaments arranged regularly and neatly, However, myocardial cell membrane wrinkles, micro-foot mutations even disappear, microbubbles disappear. This indicates that the effect of PGE2 on cardiomyocytes is time-dependent.