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采用改良的乳化-溶剂挥发法制备齐墩果酸-固体脂质纳米粒(OA-SLNs)并对其性质进行评价。其粒径,zeta电位,包封率和载药率分别为(104.5±11.7)nm,(-25.5±1.8)mV,(94.2±3.9)%,和(4.71±0.15)%。透射电子显微镜下,可见球形实心纳米粒。X-粉末衍射和差示扫描量热(DSC)图谱证实药物分子均匀分散在脂质骨架中。体外释放实验表明,OA-SLNs以每小时4.88%速率缓慢释放药物,符合零级释放动力学模型。OA-SLNs在人工胃液和肠液中具有良好的稳定性。本文研究为OA-SLNs口服给药系统的应用进一步研究提供了可能。
Oleanolic acid-solid lipid nanoparticles (OA-SLNs) were prepared by a modified emulsion-solvent evaporation method and their properties were evaluated. The particle size, zeta potential, entrapment efficiency and drug loading rate were (104.5 ± 11.7) nm, (-25.5 ± 1.8) mV, (94.2 ± 3.9)% and (4.71 ± 0.15)%, respectively. Transmission electron microscopy shows spherical solid nanoparticles. X-ray powder diffraction and differential scanning calorimetry (DSC) patterns confirmed the uniform dispersion of drug molecules in the lipid matrix. In vitro release experiments showed that OA-SLNs slowly release drug at a rate of 4.88% per hour, in line with the zero-order release kinetic model. OA-SLNs in the artificial gastric juice and intestinal fluid has good stability. This study provides the possibility of further research on the application of OA-SLNs oral delivery system.