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目的探讨CysC对早期诊断糖尿病肾损害的检测意义。方法 98例糖尿病肾病患者按照Mogensen标准I、II期为A组32例;III期为B组34例;IV期为C组32例,60例健康体检患者为对照组,对所有研究对象血清CysC,Scr,BUN进行检测分析。结果 Cys水平在A组,B组和C组均高于健康对照组,差异有统计学意义(P﹤0.01),Scr和BUN在C组与健康对照组差异有统计学意义(P﹤0.01),A组,B组与健康对照组差异无统计学意义(P﹥0.05)。结论血清胱抑素C在糖尿病肾病检测的灵敏程度高于Scr,BUN,是一种反映早期糖尿病肾损害的理想的标志物。
Objective To investigate the significance of CysC in the early diagnosis of diabetic nephropathy. Methods A total of 98 patients with diabetic nephropathy were divided into group A (32 cases) according to the Mogensen standard I, stage II, group B (34 cases), stage IV (32 cases), group C (32 cases) and healthy control group (60 cases) , Scr, BUN test analysis. Results The levels of Cys in group A, B and C were significantly higher than those in healthy controls (P <0.01). The levels of Scr and BUN in group C were significantly lower than those in healthy controls (P <0.01) There was no significant difference between A group, B group and healthy control group (P> 0.05). Conclusions Serum cystatin C is more sensitive to the detection of diabetic nephropathy than Scr and BUN, which is an ideal marker of early diabetic nephropathy.