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卓-艾综合征(Zollinger-Ellison Syndrome)作为内科急症而常威胁生命,其中胃酸过度分泌是主要原因。因此,当外科手术不得不延期时,必须抑制或者至少要显著和持久地降低胃酸分泌。用组织胺H_2-受体拮抗剂治疗卓-艾综合征已有许多非常成功的病例报道;然而,并不是所有病例均能达到显著和持久降低胃酸分泌的目的。本文报道5例卓-艾综合征应用甲氰咪胍和Pirenzepin(一种新胃酸分泌抑制剂)联合治疗获得良好结果的初步经验。方法:5例临床上有多发性和复发性溃疡、腹泻、体重减轻等表现的卓-艾综合征患者,基础胃酸分泌明显增高和空腹血清胃泌素增高,其中3例组织学
Zollinger-Ellison Syndrome as a medical emergency is often life-threatening, of which hypersecretion of gastric acid is the main reason. Therefore, when surgery has to be postponed, gastric acid secretion must be suppressed or at least significantly and permanently reduced. There are many very successful case reports of treatment of Zhuo-Ai syndrome with histamine H 2 -receptor antagonists; however, not all cases achieve a significant and sustained reduction of gastric acid secretion. This article reports on 5 cases of Zhuo-Ai syndrome application of cimetidine and Pirenzepin (a new gastric acid secretion inhibitor) combination therapy to obtain good results in the initial experience. Methods: Five cases of Zhuo-Ai syndrome with multiple recurrent ulceration, diarrhea and weight loss were found to have significantly increased basal gastric acid secretion and fasting serum gastrin. Three cases of histology