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为探讨矽肺病人不同病期血清总三碘甲腺原氨酸(TT3)、血清游离甲状腺素(FT4)、促甲状腺素(TSH)变化水平及临床意义。选取2006—2009年我科不同病期矽肺病人287例,健康体检者40例,于清晨空腹安静状态下抽取静脉血标本4 m l,采用放射免疫法测定TT3、FT4、TSH水平。在未吸氧状态下采动脉血2 m l,进行血气分析,测定动脉血氧分压(PO2)。矽肺Ⅱ期、Ⅲ期合并肺心病(急性期)病人血清TT3、FT4水平显著低于健康对照组(P<0.01)),Ⅲ期合并肺炎的病人TT3、FT4水平低于健康对照组(P<0.05)。各病期TSH无明显变化。矽肺病人上述指标的改变对判断病情的程度和预后有一定的临床价值。
To investigate the changes of serum total triiodothyronine (TT3), serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) in patients with silicosis at different stages and their clinical significance. 287 cases of silicosis and 40 healthy subjects in our department from 2006 to 2009 were selected. Venous blood samples (4 ml) were collected in fasting morning and quiet, and the levels of TT3, FT4 and TSH were measured by radioimmunoassay. Arterial blood was collected in the absence of oxygen 2 ml, blood gas analysis, determination of arterial oxygen partial pressure (PO2). The levels of TT3 and FT4 in patients with stage Ⅱ and Ⅲ pulmonary heart disease were significantly lower than those in healthy controls (P <0.01). The levels of TT3 and FT4 in patients with stage Ⅲ pneumonia were lower than those in healthy controls (P < 0.05). TSH no significant change in each stage. The above indicators of silicosis patients to determine the extent of the disease and prognosis of certain clinical value.