A new 3D velocity model of the crust and upper mantle in the southeastern(SE) margin of the Tibetan plateau was obtained by joint inversion of body-and surface-wave data. For the body-wave data, we used 7190 events recorded by 102 stations in the SE margin of the Tibetan plateau. The surface-wave data consist of Rayleigh wave phase velocity dispersion curves obtained from ambient noise cross-correlation analysis recorded by a dense array in the SE margin of the Tibetan plateau. The joint inversion clearly improves the v S model because it is constrained by both data types. The results show that at around 10 km depth there are two low-velocity anomalies embedded within three high-velocity bodies along the Longmenshan fault system. These high-velocity bodies correspond well with the Precambrian massifs, and the twolocated to the northeast of 2013 M S7.0 Lushan earthquake are associated with high fault slip areas during the 2008 Wenchuan earthquake. The aftershock gap between 2013 Lushan earthquake and 2008 Wenchuan earthquake is associated with low-velocity anomalies, which also acts as a barrier zone for ruptures of two earthquakes. Generally large earthquakes(M≥5) in the region occurring from2008 to 2015 are located around the high-velocity zones,indicating that they may act as asperities for these large earthquakes. Joint inversion results also clearly show that there exist low-velocity or weak zones in the mid-lower crust, which are not evenly distributed beneath the SE margin of Tibetan plateau. A new 3D velocity model of the crust and upper mantle in the southeastern (SE) margin of the Tibetan plateau was obtained by joint inversion of body-and surface-wave data. For the body-wave data, we used 7190 events recorded by 102 stations in the SE margin of the Tibetan Plateau. The surface-wave data consists of Rayleigh wave phase velocity dispersion curves obtained from ambient noise cross-correlation analysis recorded by a dense array in the SE margin of the Tibetan plateau. the v S model because it is constrained by both data types. The results show that at around 10 km depth there are two low-velocity anomalies embedded within three high-velocity bodies along the Longmenshan fault system. These high-velocity bodies correspond well with the Precambrian massifs, and the twolocated to the northeast of 2013 M S7.0 Lushan earthquake are associated with high fault slip areas during the 2008 Wenchuan earthquake. The aftershock gap between 2013 Lushan earthquake and 2008 Wenchuan earthquake is associated with low-velocity anomalies, which also acts as a barrier zone for ruptures of two earthquakes. Generally large earthquakes (M≥5) in the region occurred from2008 to 2015 are located around the high-velocity zones, indicating that they may act as asperities for these large earthquakes. Joint inversion results also clearly show that there exist low-velocity or weak zones in the mid-lower crust, which are not evenly distributed beneath the SE margin of Tibetan plateau.