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实验在家兔上进行。以R波触发装置所产生的单个期外刺激诱发急性缺血心脏短阵室颤,观察急性缺血早期心室易颤期的变化。此外,对缺血早期所诱发的室性心律失常的机制也进行了分析。在非缺血心脏,两倍舒张期阈强度的单个期外刺激,从不引起室颤,但在急性缺血心脏,同样强度的刺激,使所有实验动物的心脏均发生心室纤颤,并测得显颤期为45.0±27.0ms(N=6)。冠状动脉闭塞后10分钟内,以期外刺激诱发短阵室速以测定联律间期与折回间期。无论是自然心率组还是起搏心率组,其联律间期与折回间期的负相关均显著,r分别为-0.938和-0.959。这些结果提示,急性缺血早期,心室易颤期明显延长,该时间所发生的室性心律失常是由折返机制所致。
Experiments were performed on rabbits. A single extranodal stimulation induced by R wave trigger device induced acute short-circuited ventricular fibrillation in patients with acute ischemic ventricular fibrillation and observed the changes of early ventricular fibrillation during acute ischemia. In addition, the mechanism of ventricular arrhythmias induced early in ischemia was also analyzed. In a non-ischemic heart, a single extra-period stimulus at twice the diastolic threshold intensity never caused ventricular fibrillation but in the acute ischemic heart the same intensity of stimulation led to ventricular fibrillation in all experimental animals Obvious period was 45.0 ± 27.0ms (N = 6). Coronary artery occlusion within 10 minutes, extra-ventricular stimulation to induce paroxysmal ventricular tachycardia to determine the association between the law and the turn-back interval. The negative correlation between the systolic interval and the turn-around interval was significant (r = -0.938 and -0.959, respectively) in either the natural or pacing heart rate group. These results suggest that in the early stages of acute ischemia, ventricular fibrillation was significantly prolonged, ventricular arrhythmia occurred at this time is due to the mechanism of reentry.