自从1957年Ferguson-Smith首次对男性不育患者进行研究以来,已清楚男性某些染色体异常可导致不育症。Kjessler(1966,1972)无选择地调查1,263例男性不育患者,染色体异常发生率为6.6％,其中包括核型微小异常或染色体变异体,但未进行显带技术分析。Ghandly(1979)报道2,372例男性不育患者的研究结果,染色体异常为2.2％,不包括染色体变异体和微小异常。在所有调查中发现染色体异常频率随精子数降低而升高。Chandley(1979)发现精子缺乏症患者的染色体异常为15.38％;精子数在1～20百万/ml患者的染色体异常为1.76％;精子数较高(或正常)的研究组中染色体异常发生率则较低。最近细胞遗传学已成为对不育男性的研究方法之一。作者对106例精子缺乏症患者和390例精 Since the first study of male infertility by Ferguson-Smith in 1957, it has become clear that certain chromosomal abnormalities in men can lead to infertility. Kjessler (1966, 1972) investigated 1,263 male infertile patients with an unidentified frequency of chromosomal abnormalities of 6.6%, including minor karyotype or chromosomal aberrations, but no banding analysis. Ghandly (1979) reported findings in 2,372 male infertile patients with chromosomal abnormalities of 2.2%, excluding chromosomal variants and minor abnormalities. In all surveys, it was found that the frequency of chromosomal abnormalities increased as the number of sperm decreased. Chandley (1979) found a chromosomal abnormality of 15.38% in sperm deficiency patients; a chromosomal abnormality of 1.76% in sperm counts of 1 to 20 million / ml; and a chromosomal abnormality in study groups with a high (or normal) number of sperm Then lower. Recently cytogenetics has become one of the research methods for infertile men. The authors of 106 cases of sperm deficiency patients and 390 cases of fine