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脆性组氨酸三联体(fragilehistindinetriad ,FHIT)基因是1996年Ohta等〔1〕用外显子捕获法(exontrapping )确定并克隆出来的人类基因。FHIT存在于大多数正常组织中。研究发现,FHIT基因在人类多种恶性肿瘤及多种恶性肿瘤细胞系中呈现高频率的纯合缺失、杂合缺失(lossofheterozy
Fragile histone triplet (fragilehistindinetriad, FHIT) gene is 1996 Ohta et al [1] identified by exontraction (exontrapping) and cloned human genes. FHIT is present in most normal tissues. The study found that FHIT gene in human multiple malignancies and multiple malignant tumor cell lines showed high frequency homozygous deletion, loss of heterozygosis