圆头精子症是一种严重而罕见的畸形精子症,其主要特征是精子无顶体,精子头部呈圆形,可伴有卷曲的精子尾部[1]。顶体内含有精子与卵细胞结合所需的酶类,圆头精子因缺乏顶体,不能发生顶体反应,精子难以穿透卵子导致不能受精,因而临床上表现为男性不育。文献报道圆头精子症在不育男性中的发病率<0.1%[2],尽管有同胞兄弟同时患有圆头精子症和人类圆头精子症致病基因克隆成功的报道,但大部分患者的病因仍不明确,可能为未知致 Round sperm disease is a serious and rare deformity sperm disease, its main feature is sperm acrosome, sperm head is round, may be accompanied by curly sperm tail [1]. Acrosome contains sperm and egg cells required enzymes, round head sperm due to the lack of acrosome, can not occur acrosome reaction, sperm difficult to penetrate the egg lead to not fertilize, so clinically manifested as male infertility. In the literature, the incidence of round spermatozoa in infertile men is less than 0.1% [2]. Although siblings have successfully reported both round spermatozoa and human round spermatozoa, The cause of the disease is still unclear and may be unknown