论文部分内容阅读
目的观察拉米夫啶联合苦参素治疗慢性乙型肝炎的临床疗效。方法治疗组50例应用拉米夫啶0.1g每日1次,服用1年以上,同时应用苦参素600mg/100ml静脉滴注,每日1次,2月个后改为200mg口服6个月。对照组46例,单用拉米夫啶,观察病人HBV-DNA、HBV标志物、肝功能变化。结果治疗组HBV-DNA、HBeAg阴转、肝功能复常率、临床表现改善明显高于对照组。YMDD变异发生率低于对照组。结论拉米夫啶联合苦参素治疗慢性乙型肝炎可显著提高抗病毒的疗效,对肝功能复常、临床症状改善疗效明显优于单用拉米夫啶。
Objective To observe the clinical efficacy of lamivudine combined with oxymatrine in the treatment of chronic hepatitis B. Methods 50 patients treated with lamivudine 0.1g 1 day, taking more than 1 year, while the application of oxymatrine 600mg / 100ml intravenous infusion, once daily, 200mg after a month to 200mg orally for 6 months . Control group, 46 cases, lamivudine alone, observed in patients with HBV-DNA, HBV markers, liver function changes. Results The treatment group, HBV-DNA, HBeAg overcast, liver function recovery rate, clinical manifestations improved significantly higher than the control group. The incidence of YMDD mutation was lower than that of the control group. Conclusion Lamivudine combined with oxymatrine treatment of chronic hepatitis B can significantly improve the efficacy of antiviral therapy for liver function, clinical symptoms improved significantly better than lamivudine alone.