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作者对85例经金剂治疗的类风湿性关节炎病人进行 HLA-A、B、C、D 位点抗原检测,探讨金剂治疗所致不同毒性作用与不同 HLA 抗原的关系。据治疗后发生的不同毒性作用,将病人分成4组:①间质性肺炎组16例;②皮肤粘膜损害组26例;③蛋白尿组20例;④无毒副作用组23例。以283名正常健康人作对照。
The authors tested the HLA-A, B, C and D antigen in 85 cases of rheumatoid arthritis patients treated with gold agents, and explored the relationship between different toxic effects caused by gold agents and different HLA antigens. According to the different toxic effects after treatment, the patients were divided into 4 groups: ① interstitial pneumonia in 16 cases; ② skin and mucosal damage in 26 cases; ③ proteinuria in 20 cases; ④ non-toxic side effects in 23 cases. To 283 normal healthy controls.