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平滑肌中的兴奋—收缩耦联机制平滑肌、心肌和骨骼肌的收缩需要收缩蛋白——肌动蛋白和肌凝蛋白——的相互作用。平滑肌的肌动蛋白和肌凝蛋白的一般分子结构和横纹肌者相似。然而,钙调节平滑肌和横纹肌中肌动蛋白—肌凝蛋白相互作用的机制则有不同。环化腺苷3’:5’磷酸酯(环磷腺苷cAMP)在调节激素和药物对肌肉收缩和松弛的作用中起有重要的作用。直至最近,环磷腺苷对平滑肌收缩的可能直接作用的机制,仍然不明。本文旨在复习钙和环磷腺苷调节平滑肌肌动蛋白和肌凝蛋白相互作用机制的资料。
Excitation in Smooth Muscles - Shrinkage Coupling Mechanism Contractions of contractile proteins, actin and myosin, are required for the contraction of smooth muscle, myocardium and skeletal muscle. The general molecular structure of smooth muscle actin and myosin is similar to those of the striated muscle. However, the mechanism by which calcium modulates the actin-myosin interaction in smooth muscle and striated muscle is different. Cyclic adenosine 3 ’: 5’ phosphate (cyclic adenosine monophosphate cAMP) plays an important role in regulating the effects of hormones and drugs on muscle contraction and relaxation. Until recently, the mechanism by which cyclic adenosine monophosphate may have a direct effect on smooth muscle contraction remains unclear. This article aims to review data on the mechanisms by which calcium and cyclic adenosine regulates the interaction between smooth muscle actin and myosin.