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目的:观察对左心室舒张末容积增大的早期治疗与心力衰竭的关系。方法:选择有心力衰竭的高危患者200例(左心室舒张末容积>90 ml/m2,超声心动图测定心功能仍正常),随机分为对照组和治疗组。对照组采用综合疗法,治疗组在上述基础上加用依那普利(2.5~20 mg/d)。在治疗前和观察期2 a内分别对左心室舒张末容积以及心功能测定,以了解其动态变化与心力衰竭的关系。结果:左心室舒张末容积缩小,LVEF无下降,血压下降。结论:左心室舒张末容积增大、心功能正常的患者极早使用血管紧张素转换酶抑抑制剂(ACEI),能防止出现心力衰竭。
Objective: To observe the relationship between early treatment of left ventricular end-diastolic volume and heart failure. Methods: 200 high risk patients with heart failure (left ventricular end diastolic volume> 90 ml / m2, echocardiographic determination of cardiac function still normal) were randomly divided into control group and treatment group. In the control group, the combination therapy was used. The treatment group received enalapril (2.5-20 mg / d) on the basis of the above. Left ventricular end-diastolic volume and cardiac function were measured before and during the observation period to find out the relationship between dynamic changes and heart failure. Results: Left ventricular end-diastolic volume reduced, LVEF no decline, blood pressure decreased. CONCLUSION: Left ventricular end-diastolic volume is increased, and patients with normal cardiac function have very early use of angiotensin-converting enzyme inhibitor (ACEI) to prevent heart failure.