【摘 要】
：
Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs.An i
【机 构】
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College of Chemistry and Materials,Sichuan Normal University,
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs.An intramolecular oxidative coupling reaction of unfunctionalized 2,3-disubstituted phenyl acrylic acids and derivatives promoted by di-rerr-butylperoxide gave above intermediates in high yields.The mild reaction conditions and easy purification procedures of this method provide a new approach for the synthesis of phenanthrenes.
Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs. An intramolecular oxidative coupling reaction of unfunctionalized 2,3-disubstituted phenyl acrylic acids and derivatives promoted by di-rerr-butylperoxide gave above intermediates in high yields.The mild reaction conditions and easy purification procedures of this method provide a new approach for the synthesis of phenanthrenes.
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