3例出生于其母为HBsAg阳性、e抗体(抗-HBe)亦为阳性的婴儿,于出生后3个月发展为急性黄疸型乙型肝炎。3例婴儿全部临床症状缓解,而血循环中产生了表面抗体。和从前的研究相反,这3个病例证明:乙型肝炎病毒母婴间的垂直传播,可发生于婴儿出生时,其母为HBsAg阳性而e抗原为阴性者。这些婴儿可发展为很严重的急性黄疸型肝炎,因此,在这些新生儿中免疫预防是有指征的。 3 cases were born in infants whose mothers were HBsAg positive and e antibody (anti-HBe) were also positive and developed acute jaundice hepatitis B 3 months after birth. All 3 infants had their clinical symptoms relieved, while surface antibodies were produced in the circulation. Contrary to previous studies, these three cases demonstrated that the vertical transmission of hepatitis B virus (HBV) between maternal and infants can occur at the birth of a baby whose mother is HBsAg positive and whose e antigen is negative. These babies develop severe acute jaundice hepatitis, so immunoprophylaxis is an indication in these newborns.