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目的 了解白细胞介素 -6(IL -6)在鉴别呼吸系统感染性疾病与肺癌的价值 ,以及与非小细胞肺癌 (NSCLC)的分期、分型的关系。方法 选择NSCLC患者 61例 (肺癌组 ) ,呼吸系统感染者 3 6例 (感染组 )及健康献血员 3 0例 (正常组 ) ,用酶联免疫吸附法 (ELISA)测定各组血清IL -6水平进行比较。结果 肺癌组血清IL -6水平 ( 11 80 3± 8 3 5 7)ng/ml明显高于正常组 ( 7 2 63±4 3 65 )ng/ml(P <0 0 1) ,而低于感染组 ( 17 414± 17 12 8)ng/ml(P <0 0 5 ) ;随着肺癌分期的增高 ,IL -6的水平有逐渐增高的趋势 ,肺癌组内各型间IL -6水平无显著性差异。结论 血清IL -6水平与NSCLC的分期有关 ,动态随访可为NSCLC的预后提供参考 ;结合临床资料 ,可作为NSCLC与呼吸系统感染性疾病的辅助鉴别指标之一。
Objective To investigate the value of interleukin-6 (IL-6) in the differential diagnosis of respiratory diseases and lung cancer, and its relationship with staging and typing of non-small cell lung cancer (NSCLC). Methods Sixty-one NSCLC patients (lung cancer group), 36 respiratory infection patients (infection group) and 30 healthy blood donors (normal group) were selected for the study. Serum IL-6 levels were measured by enzyme-linked immunosorbent assay Level comparison. Results The level of IL-6 in lung cancer group was significantly higher than that in the normal group (11 80 3 ± 8 3 5 7) ng / ml (7263 ± 4355) ng / ml (P 0 01) (17 414 ± 17 12 8) ng / ml (P <0.05). With the increase of lung cancer staging, the level of IL-6 tended to increase gradually. There was no significant difference in the level of IL-6 among all the types of lung cancer Sex differences. Conclusions Serum IL-6 level is related to the stage of NSCLC. Dynamic follow-up may provide a reference for the prognosis of NSCLC. Combined with clinical data, it can be used as an auxiliary index for identifying NSCLC and respiratory infectious diseases.