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目的观察亚慢性镉中毒性肝肾损害，并初步探讨金属硫蛋白（ＭＴ）与肝肾损害的关系。方法用Ｗｉｓｔａｒ大鼠腹腔注射０．５ｍｇ／ｋｇＣｄ２＋的ＣｄＣｌ２３次／周，共１０周，染毒后不同时期处死大鼠，观察肝肾功能变化。结果染毒６周后，大鼠出现了明显的肝肾损害，相应组织中Ｃｄ∶ＭＴ的摩尔数之比均超过７，且随染毒总剂量的增加，Ｃｄ∶ＭＴ值明显增加，病变程度加重。结论肝肾是亚慢性镉中毒的靶器官，非ＭＴ结合的镉可能是损害肝、肾的主要成分。
Objective To observe the sub-chronic cadmium poisoning of liver and kidney damage, and to explore the relationship between metallothionein (MT) and liver and kidney damage. Methods Wistar rats were intraperitoneally injected with 0.5mg / kg Cd2 + CdCl23 0.5 times / week for 10 weeks. Rats were sacrificed at different periods after exposure to observe the changes of liver and kidney function. Results After six weeks of exposure, the rats showed obvious liver and kidney damage. The ratios of the molar number of Cd: MT in the corresponding tissues were all over 7, and the Cd: MT value increased obviously with the increase of the total dose. Increase. Conclusion Liver and kidney are the target organs of subchronic cadmium poisoning. Non-MT bound cadmium may be the main component that damages the liver and kidney.