论文部分内容阅读
目的探讨乙肝血清中Pre-S1抗原与HBeAg及HBV-DNA之间的关系,以确定其临床意义。方法对160例乙型肝炎患者血清中Pre-S1、HBV-M、HBV-DNA进行检监测,对其结果进行比较分析。结果在HBsAg阳性的160例患者血清中Pre-S1与HBV-DNA的检出率分别为70.6%和78.1%,Pre-S1与HBV-DNA检出符合率达90.4%。结论Pre-S1抗原可作为HBV感染的血清学指标初步指标。能够较好地反映乙肝病毒复制情况,对病情的预后及疗效判断具有指导意义。
Objective To investigate the relationship between serum Pre-S1 antigen and HBeAg and HBV-DNA in hepatitis B virus (HBV) to determine its clinical significance. Methods The serum levels of Pre-S1, HBV-M and HBV-DNA in 160 patients with hepatitis B were monitored and the results were compared. Results The positive rates of Pre-S1 and HBV-DNA in sera of 160 HBsAg-positive patients were 70.6% and 78.1%, respectively. The coincidence rate of Pre-S1 and HBV-DNA was 90.4%. Conclusion Pre-S1 antigen can be used as a primary index of serological markers of HBV infection. Can better reflect the replication of hepatitis B virus, the prognosis of the disease and determine the efficacy of guidance.