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目的研究普拉克索治疗帕金森病非运动症状的临床效果。方法随机选取广东省江门市中心医院2013年6月至2014年6月收治的78例帕金森患者,分为两组,给予对照组患者多巴丝肼治疗,研究组则在对照组治疗基础上联合普拉克索,观察研究两组临床治疗效果。结果治疗后,两组肢体浮肿及不良反应发生率比较差异未见统计学意义(P>0.05);但研究组睡眠障碍、感觉异常、排尿异常以及性功能障碍等发生率较对照组发生率低,且研究组HAMD及UPDRSⅢ评分优于对照组,差异有统计学意义(P<0.05)。结论给予帕金森病患者普拉克索治疗能够有效改善其睡眠障碍、感觉异常、排尿异常以及性功能障碍等非运动症状,且无明显不良反应,值得在临床上推广应用。
Objective To study the clinical effect of pramipexole in the treatment of non-motor symptoms of Parkinson’s disease. Methods A total of 78 patients with Parkinson’s disease admitted from June 2013 to June 2014 in Central Hospital of Jiangmen City, Guangdong Province were selected randomly and divided into two groups. Patients in the control group were treated with basal hydrazine. The study group was treated on the basis of the control group Combined with pramipexole, observe the clinical treatment effect of two groups. Results After treatment, there was no significant difference in the incidence of edema and adverse reactions between the two groups (P> 0.05). However, the incidence of sleep disorders, sensory abnormalities, voiding dysfunction and sexual dysfunction in the study group were lower than those in the control group , And the scores of HAMD and UPDRSⅢ in the study group were better than those in the control group (P <0.05). Conclusions Pramipexole treatment for patients with Parkinson’s disease can effectively improve non-motor symptoms such as sleep disorders, sensory abnormalities, voiding dysfunction and sexual dysfunction without obvious adverse reactions, which is worth popularizing in clinic.