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目的：了解丁型肝炎病毒（ＨＤＶ）对ＨＢＶ感染者病情的影响及其感染现状。方法：ＨＢＶ ＤＮＡ采用ＰＣＲ法；ＨＢＶＭ，ＨＤＡｇ，抗－ＨＤＩｇＭ，抗－ＨＤ采用酶联免疫吸附法。结果：乙型肝炎（乙肝）患者中丁型肝炎感染率８．６２％，单纯乙肝、重叠感染在急慢性肝炎、肝硬化中比率有显著性差异，ＨＢｅＡｇ，ＨＢＶ ＤＮＡ 阳性率在各型肝炎中均无明显差异，重叠感染慢性重症肝炎病死率高，与单纯乙肝有显著性差异。结论：ＨＤＶ感染使乙肝患者肝硬化增加，慢性重症肝病病情加重，但不影响ＨＢＶ复制。
Objective: To understand the effect of hepatitis D virus (HBV) on the condition of HBV infected persons and its status of infection. Methods: HBV DNA was detected by PCR, HBVM, HDAg, anti-HDIgM and anti-HD by enzyme-linked immunosorbent assay. Results: The prevalence of hepatitis D in patients with hepatitis B (hepatitis B) was 8.62%. There was a significant difference in the rates of hepatitis B and overlap infection between acute and chronic hepatitis and cirrhosis. The positive rates of HBeAg and HBV DNA in hepatitis B No significant difference, overlapping infection of chronic severe hepatitis mortality is high, with a significant difference between hepatitis B alone. Conclusions: HDV infection increases cirrhosis of patients with hepatitis B and exacerbations of chronic severe liver disease, but does not affect HBV replication.