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急性白血病的病因迄今未明,国内外有氯霉素引起白血病的报导,但灰黄霉素引起白血病尚未见有关记载。我院1975年收治一例因接受灰黄霉素治疗足癣发生造血障碍的自血病,报告如下: 病例报告患者,男,29岁,住院号314311,未婚,1975年9月17日入院。患者于10天前起发热,畏寒,全身骨痛,腹痛,无腹泻及呕吐,验血发现白细胞1000/立方毫米,淋巴90％,曾因白细胞减少原因待查入当地医院检查治疗,反复输血三次,骨髓穿刺二次未成功,周围血白细胞进行性减少,无出血倾向。过去病史:一向健康,发病前4个月因足癣服灰黄霉素50多片,服药后一月余,先后三次出现头晕乃至晕倒,片刻即醒。
The cause of acute leukemia has not yet been identified, chloramphenicol caused leukemia at home and abroad, but griseofulvin-induced leukemia has not been documented. In 1975, our hospital admitted a case of hematopathy due to receiving griseofulvin for the treatment of hematopoietic disorders of tinea pedis. The report was as follows: A case report patient, male, 29 years old, hospitalized 314311, unmarried, admitted to hospital on September 17, 1975. Patients ten days ago, fever, chills, body pain, abdominal pain, no diarrhea and vomiting, blood tests found white blood cells 1000 / cubic millimeter, 90% of lymph nodes, had due to leukopenia to be checked into the local hospital for examination and treatment, repeated blood transfusion Three times, bone marrow biopsy was unsuccessful, peripheral blood leukocytes progressive reduction, no bleeding tendency. Past medical history: always healthy, 4 months before onset due to tricuspidosis griseofulvin more than 50 tablets, taking more than a month after taking medicine, has three times dizziness and fainted, a moment to wake up.