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目的探讨双水平正压通气(BiPAP)联合盐酸氨溴索对慢性阻塞性肺疾病(COPD)患者血气指标的影响。方法将92例COPD患者随机分为两组,对照组46例仅进行BiPAP治疗,观察组46例在BiPAP治疗后加用盐酸氨溴索,治疗2周后观察血气指标变化。结果观察组治疗总有效率高于对照组(P<0.05);观察组临床症状缓解时间短于对照组(P<0.05);两组治疗后血pH比较差异无统计学意义(P>0.05);观察组氧分压(PaO2)、血氧饱和度(SpO2)高于对照组(P<0.01),二氧化碳分压(PaCO2)低于对照组(P<0.01)。结论 BIPAP联合盐酸氨溴索可改善COPD患儿血气指标,提高患者耐受性,促进临床症状消除。
Objective To investigate the effect of bi-level positive pressure ventilation (BiPAP) combined with ambroxol hydrochloride on blood gas indexes in patients with chronic obstructive pulmonary disease (COPD). Methods Ninety-two patients with COPD were randomly divided into two groups. 46 patients in the control group were treated with BiPAP only. 46 patients in the observation group were treated with ambroxol hydrochloride after BiPAP treatment. The changes of blood gas index were observed after 2 weeks of treatment. Results The total effective rate of observation group was higher than that of control group (P <0.05); the clinical symptom relief time in observation group was shorter than that of control group (P <0.05); there was no significant difference in blood pH after treatment between two groups (P> 0.05) ; PaO2 and SpO2 in the observation group were higher than those in the control group (P <0.01), PaCO2 was lower than the control group (P <0.01). Conclusion BIPAP combined with ambroxol hydrochloride can improve blood gas in COPD children, improve patient tolerance and promote the elimination of clinical symptoms.