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目的:调查新疆维吾尔族食管鳞癌患者中人乳头瘤状病毒(HPV)16型的感染率.方法:采用PCR技术检测82例新疆维吾尔族食管鳞癌和80例癌旁正常食管黏膜石蜡包埋组织HPV16的感染率,分析其与新疆维吾尔族食管鳞癌发生的关联性.结果:在新疆维吾尔族食管鳞癌组织中,HPV16型检出率为31.7%(26/82),与对照组12.5%(10/80)相比,差异有统计学意义(χ2=8.643,P<0.05);按照年龄、性别、病理分化程度及临床分期对维吾尔族食管鳞癌中的HPV16感染状况比较,差异均无统计学意义(χ2=0.301、0.149、2.876、0.105,均P>0.05).结论:HPV16型感染与新疆维吾尔族食管鳞癌的发生存在一定的相关性,但与患者的年龄、性别、病理分化程度及临床分期无明显的关联性.
Objective: To investigate the infection rate of human papillomavirus (HPV) type 16 in esophageal squamous cell carcinoma of Uygur Xinjiang.Methods: 82 cases of Uygur esophageal squamous cell carcinoma and 80 cases of adjacent normal esophageal mucosa paraffin embedded HPV16 infection rate was analyzed and its association with esophageal squamous cell carcinoma was analyzed.Results: The detection rate of HPV16 was 31.7% (26/82) in Uygur esophageal squamous cell carcinoma in Xinjiang, which was significantly higher than that in control group 12.5 (Χ2 = 8.643, P <0.05). According to the age, sex, pathological differentiation degree and clinical stage, the differences of HPV16 infection in Uigur esophageal squamous cell carcinoma were statistically significant (Χ2 = 0.301,0.149,2.876,0.105, all P> 0.05) .Conclusion: There is a correlation between HPV16 infection and the occurrence of Uygur esophageal squamous cell carcinoma in Xinjiang, but not with age, sex, pathology Differentiation and clinical stage no significant correlation.