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氟芬那酸丁酯是一种灭酸类非甾体抗炎镇痛药,其作用机制是阻止细胞内花生四烯酸生成前列腺素和白三烯等炎症介质以及稳定溶酶体膜阻止炎症进一步扩散和加重。外用氟芬那酸丁酯软膏在皮肤病方面的作用广泛,无全身不良反应,仅有局部刺激,且适用于儿童等优点。该文对氟芬那酸丁酯软膏的药理作用和临床用途及不良反应等方面的研究进展做一综述。
Flufenamic acid butyl ester is a kind of acaric acid nonsteroidal anti-inflammatory analgesic, its mechanism of action is to prevent intracellular arachidonic acid to produce prostaglandins and leukotrienes and other inflammatory mediators and stabilize the lysosomal membrane to prevent inflammation Further proliferation and aggravating. Topical flufenamic acid butyl ester ointment in the role of a wide range of skin diseases, no systemic adverse reactions, only partial stimulation, and for children and other advantages. This article reviews the pharmacological effects, clinical uses and side effects of flufenamic acid butyl ester ointment.