自1975年Carswell等提出“肿瘤坏死因子”(TNF—α)的概念以来,这一领域的研究已有了突飞猛进的发展,1984年两类TNFCDNA相继克隆成功,并制备出相应的重组产品,到90年代对它的研究有了进一步的发展。作为一种细胞因子它具有多种生物学效应,除具备抗肿瘤、抗病毒、参与炎症、脂代谢、免疫、骨质重建外,近年来许多国内外学者研究发现TNF—α与妊娠密切相关,现综述如下。 Since the concept of “tumor necrosis factor” (TNF-α) was proposed by Carswell et al in 1975, the research in this field has progressed by leaps and bounds. Two types of TNFCDNAs were successfully cloned in 1984 and the corresponding recombinant products were prepared. In the 90’s, its research has been further developed. As a cytokine, it has a variety of biological effects, in addition to having anti-tumor, anti-virus, involved in inflammation, lipid metabolism, immune, bone remodeling, in recent years, many domestic and foreign scholars found that TNF-α and pregnancy are closely related, Are summarized below.