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我院从1978年2月至1988年12月,采用液氮冷冻治疗唇部肿瘤120例,其中唇癌100例,占83.3％。 临床资料 100例中,男78例,女22例,男女比为3.5:1。年龄最小38岁,最大89岁,平均63岁。病程最短半月,最长20年,平均2年,肿瘤位于上唇27例,下唇70例,口角3例,病理类型:鳞癌86例,基底细胞癌9例,角化病癌变2例,原位癌、粘液表皮样癌和皮角癌变各1例。按国际抗癌联盟TNM分期标准,T_1 37例,T_2 49例,T_3 6例,T_4 8例。 治疗方法 以液氮作致冷剂,采用接触法、灌注法和喷射法治疗。对较小瘤体多用接触法。较大瘤体多用灌注法,菜花状或溃疡型多用喷射法。冷冻时一般不用止痛药。无论采用何种冷冻方式,每次治疗均应完成3个以上冻融周期。冻结后形成的冰缘应距瘤体O。
In our hospital from February 1978 to December 1988, 120 cases of lip tumor were treated with liquid nitrogen cryotherapy, including 100 cases of lip cancer, accounting for 83.3%. Clinical data In 100 cases, there were 78 males and 22 females with a male to female ratio of 3.5:1. The youngest is 38 years old and the oldest is 89, with an average of 63 years old. The shortest course of the disease lasted for 20 months, with an average of 2 years. The tumor was located in the upper lip in 27 cases, the lower lip in 70 cases, and the mouth angle in 3 cases. The pathological types were: squamous cell carcinoma in 86 cases, basal cell carcinoma in 9 cases, and keratosis in 2 cases. There were 1 case of cancer, mucoepidermoid carcinoma and keratoconus carcinoma. According to the International Union Against Cancer Union (TNM) staging criteria, there were 37 T_1 cases, 49 T_2 cases, T_36 cases, and T_4 cases. Treatments Liquid nitrogen was used as a refrigerant and contact, perfusion and sparging treatments were used. Use multiple contact methods for smaller tumors. Larger tumors are often used for perfusion, cauliflower-like or ulcer-type sprays. Generally do not use painkillers when freezing. No matter what kind of freezing method is used, more than 3 cycles of freezing and thawing should be completed for each treatment. The ice edge formed after freezing should be away from the tumor body O.