论文部分内容阅读
探讨皮下注射雨蛙肽对束缚-浸水引起的大鼠应激性胃粘膜损伤的影响及其机理。结果:①皮下注射雨蛙肽,可明显地减轻大鼠应激性胃粘膜损伤,并在一定的剂量范围内呈现量效关系;②预先皮下注射消炎痛(5mg/kg),可阻断雨蛙肽的抗胃粘膜损伤作用;③皮下注射雨蛙肽,可降低应激大鼠胃粘膜中丙二醛的含量;④电镜观察结果,皮下注射雨蛙肽能抑制应激大鼠胃粘膜壁细胞胃酸分泌的增加。结果表明,雨蛙肽的抗胃粘膜损伤作用可能由内源性前列腺素所中介,并与其清除自由基有关,还通过抑制应激大鼠的胃酸分泌而实现。
To investigate the effect of subcutaneous injection of frog peptides on stress-induced gastric mucosal injury induced by binding-immersion in rats and its mechanism. RESULTS: 1Subcutaneous injection of cerulein could significantly relieve stress-induced gastric mucosal injury in rats and show a dose-effect relationship within a certain dose range. 2Pre-subcutaneous injection of indomethacin (5 mg/kg) blocked cerulein The role of anti-gastric mucosal injury; 3 subcutaneous injection of cerulein can reduce the content of malondialdehyde in the gastric mucosa of stressed rats; 4 electron microscopy observation, subcutaneous injection of cerulein can inhibit gastric acid secretion of gastric mucosal cells in stress rats. increase. The results showed that the anti-gastric mucosal damage of cerulein could be mediated by endogenous prostaglandins and related to its scavenging of free radicals. It also was achieved by inhibiting gastric acid secretion in stressed rats.